Variant Asthma

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What is asthma? In many people, asthma appears to be an allergic reaction to substances commonly breathed in through the air, such as animal dander, pollen, or dust mite and cockroach waste products. The catch-all name for these substances, allergens, refers to anything that provokes an allergic reaction. Some people have a genetic predisposition to react to certain allergens.

When these people breathe in the allergen, the immune system goes into high gear as if fighting off a harmful parasite. The system produces a molecule called immunoglobulin E (IgE), one of a class of defensive molecules termed antibodies. The IgE antibody is central to the allergic reaction. For example, it causes mast cells, a type of specialized defensive cell, to release chemical 'weapons' into the airways. The airways then become inflamed and constricted, leading to coughing, wheezing, and difficulty breathing -- an asthma attack.

Without treatment, such as inhaled corticosteriods to reduce the inflammation, asthma attacks can be deadly. The overall death rate for asthma, however, is low. - NIAID

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